I don't know how long it takes most... My neuro prescribed 300 mg of Neurontin 3xs a day about a year ago. He told me to take the first dose when I didn't have to drive or anything so I would know how it would effect me. Within an hour, I was laid out on the couch - couldn't open my eyes, but didn't go to sleep either. That part wore off about an hour later, but I always felt drugged on it. I now take 100 mg of Lyrica every night. It works like a charm on the pain and don't have any ill effects from it. I wish the cost was better... I don't take Elavil, so i can't help you there. I take zoloft - it doesn't seem to have any effect (except a side effect of saneness or calmness....

) My SIL took it and had to get off of it b/c it made her sleep so much. I guess different meds effect us all different ways. The most important thing is that it helps you and you are pain free!