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The ABC Café  |  Public Forum: Dealing with Bone Cancer  |  Diagnosis and Treatment  |  Topic: Shortened Interval Between Chemo Cycles for Osteosarcoma? « previous next »
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Author Topic: Shortened Interval Between Chemo Cycles for Osteosarcoma?  (Read 4807 times)
Mary
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« on: February 07, 2007, 10:08:18 AM »

According to the results of a study published in the Journal of the National Cancer Institute, osteosarcoma patients treated with the chemotherapy drugs cisplatin and doxorubicin every two weeks did not have better survival than patients who received the same drugs every three weeks.

In summary, this was one of the largest trials in osteosarcoma, and it tested the use of dose-intensified perioperative chemotherapy. Planned intensification of chemotherapy with cisplatin and doxorubicin increased received dose intensity and resulted in a statistically significant increase in favorable histologic response rate, but not in increased progression-free or overall survival. Our results call into question the use of histologic response as a surrogate outcome measure in trials of this disease.

Full study here.  Username is abcgroup, password abcgroup for all full research articles.
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Mary, ABC Founder, Parosteal Osteosarcoma Survivor - Humerus Resection 12/03, no chemo
*I am not a doctor. Nothing in this message is medical advice. Please consult your physician.*
Cari
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« Reply #1 on: February 07, 2007, 09:56:57 PM »

Thanks Mary,
I always wondered how they came up with ideas as far as how much and how often--that is an interesting study--Just goes to show no 2 people are alike Smiley
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Cari, Osteosarcoma survivor, diagnosed 8/2003
lots of chemo, 1-6-04 limbsalvage rt knee & tibia, more chemo--
12/05-patella replacement surgery
11/06 - surgery cyst and scar tissue
3/07-rt lung mets-removed; 4/07 surgery scar tissue
3/09- lung mets removed;4/09 Above Knee amputation
AC-again
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The ABC Café  |  Public Forum: Dealing with Bone Cancer  |  Diagnosis and Treatment  |  Topic: Shortened Interval Between Chemo Cycles for Osteosarcoma? « previous next »
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